ACDBio
BaseScope™ Probe- BA-Mm-Cox10-3zz-st-C2
1047211-C2
Info:Supplier Page
COX is the terminal enzyme of the respiratory chain that, catalyzes the transfer of electrons from reduced cytochrome c to molecular oxygen. We deleted the Cox10 gene that encodes for one of the accessory proteins of Complex IV. We found that astrocyte-specific deletion of Cox10 and resultant deficiency of Complex IV and oxidative phosphorylation attenuated novel object recognition and trace fear conditioning. The findings suggest that astrocyte oxidative phosphorylation may contribute to behaviors associated with greater cognitive load and stressful conditions.
BaseScope ISH
Mouse brain sample
Keep in mind that dilution should be 1:50
To assess regional changes in expression of Cox10 mRNA, we used BaseScope in situ hybridization and found an approximately 50%-decrease in expression of Cox10 in the dentate gyrus of the hippocampus, the CA1-CA2 areas of the hippocampus and the caudate putamen.
35275429
Very clear and bright signal.
The big price for pretty small volume of probe.
Highly recommend to use for BaseScope assay.