Phospho-EGF Receptor (Tyr845) (D63B4) Rabbit mAb 6963S from Cell Signaling Technology

Product Specs
ItemPhospho-EGF Receptor (Tyr845) (D63B4) Rabbit mAb
CompanyCell Signaling Technology
Price Pricing Info Supplier Page View Company Product Page
Catalog Number6963S
Quantity100 µl
ApplicationsW, IP
ReactivityH
TargetEGFR (Tyr869) phosphate
ModificationsEGFR (Tyr869) phosphate
HostRabbit
NCBI Gene AliasesERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA
ClonalityMonoclonal
NCBI Full Gene Nameepidermal growth factor receptor
Research AreaRTK
IsotypeIgG
CloneD63B4
Molecular Weight175

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Germline mutations and developmental mosaicism underlying EGFR-mutant lung cancermedRxivOctober 4, 2023Risa Burr, Ignaty Leshchiner, Christina L Costantino, Martin Blohmer, Tilak Sundaresan, Justin Cha, Karsen Seeger, Sara Guay, Brian P Danysh, Ira Gore, et al.#4267 1:500 dilution in 5% BSA in PBST, imaged on LiCor); EGFR pY845 (Cell Signaling Technologies #6963 1:500 dilution in 5% BSA in PBST, imaged on LiCor); Akt1/2 (Cell Signaling Technologies #9272 1:1000

(2) ERBB family fusions are recurrent and actionable oncogenic targets across cancer typesFrontiers in OncologyApril 24, 2023Laura Schubert, Andrew Elliott, Anh T. Le, Adriana Estrada-Bernal, Robert C. Doebele, Emil Lou, Hossein Borghaei, Michael J. Demeure, Razelle Kurzrock, Joshua E. Reuss, et al.from Selleck Chemicals. AKT pS437 (4058), AKT (2920), ERK pT202/Y204 (9101), ERK (9107), EGFR pY845 (6963) and HER2 pY877 (2241) were purchased from Cell Signaling Technology. EGFR (610017) and HER2 (610161)

(3) LMNA Reduced Acquired Resistance to Erlotinib in NSCLC by Reversing the Epithelial-Mesenchymal Transition via the FGFR/MAPK/c-fos Signaling PathwayInternational journal of molecular sciencesOctober 31, 2022Hu C, Zhou A, Hu X, Xiang Y, Huang M, Huang J, Yang D, Tang Y.TX, USA, sc-81485), c-fos (ZEN Bio, Chengdu, China, 340249), p-EGFRY845 (Cell Signaling Technology, 6963), and GAPDH (SAB, MD, USA, 48142). 4.2. RNA Sequencing Analysis RNA sequencing (RNA-seq) and RNA-seq

(4) Propofol induces apoptosis and ameliorates 5‑fluorouracil resistance in OSCC cells by reducing the expression and secretion of amphiregulinMolecular medicine reportsJanuary 1, 2022Yang KS, Che PC, Hsieh MJ, Lee IN, Wu YP, Chen MS, Chen JC.(1:200; cat. no. sc-74501; Santa Cruz Biotechnology, Inc.), phosphorylated (p)-EGFR (1:1,000; cat. no. 6963S; Cell Signaling Technology, Inc.), and EGFR (1: 200; cat. no. sc-53274; Santa Cruz Biotechnology, Inc.).

(5) RAB31 marks and controls an ESCRT-independent exosome pathwayCell researchFebruary 1, 2021Wei D, Zhan W, Gao Y, Huang L, Gong R, Wang W, Zhang R, Wu Y, Gao S, Kang T.rabbit antibody (1:1000; Cell Signaling; 4267), p-Y845 EGFR rabbit antibody (1:1000; Cell Signaling; 6963), p-Y1068 EGFR rabbit antibody (1:2000; Cell Signaling; 3777), p-Y1173 EGFR rabbit antibody (1:1000;

(6) Fibroblast growth factor receptor facilitates recurrence of minimal residual disease following trastuzumab emtansine therapyNPJ breast cancerJanuary 21, 2021Akhand SS, Chen H, Purdy SC, Liu Z, Anderson JC, Willey CD, Wendt MK.with 1:1000 dilutions of antibodies specific for pERK1/2 (9101), pHER2 (2243), pAKT (4060), pEGFR (6963), AKT (4685), EGFR (4267), ERR1/2 (4695), FGFR1 (9740), HER2 (4290; Cell signaling Technologies), E-cadherin

(7) Quantitative Tyrosine Phosphoproteomic Analysis of Resistance to Radiotherapy in Nasopharyngeal Carcinoma CellsCancer Management and ResearchDecember 9, 2020Lin Shen, Zhanzhan Li, Liangfang Shenchemiluminescence detection reagent (Abcam, Cambridge, MA). The primary antibodies used were phosphoEGFR Y869 (6963; Cell Signaling), epidermal growth factor receptor (EGFR) (4267; Cell Signaling), phospho-EPHA2 Y772

(8) SRC and PIM1 as potential co-targets to overcome resistance in MET deregulated non-small cell lung cancerTranslational Lung Cancer ResearchNovember 19, 2020Ilaria Attili et al.(Y1068),"1:1,000",Cell signaling (#3777) Rabbit anti-Phospho-EGFR (Y845),"1:1,000",Cell signaling (#6963) Rabbit anti-ERK1/2,"1:1,000",Cell signaling (#9102) Rabbit anti-PhosphoERK1/2 (T202/Y204),"1:1,000",Cell signaling

(9) Alterations in EGF-Endocytosis, Lysosomal Enzyme Transport and Maturation of Cathepsins in Juvenile Neuronal Ceroid Lipofuscinosis FibroblastsInternational Clinical Neuroscience JournalDecember 23, 2019Jaime Cárcel-Trullolsfrom Peptide Institute, Inc. Phosphospecific antibodies that recognize phosphorylated (Tyr-845)-EGFR (#6963) were purchased from Cell Signalling. Specific antibodies that recognize total EGFR (ab2430), used in western blot

(10) SRC and MEK Co-inhibition Synergistically Enhances the Anti-tumor Effect in Both Non-small-cell Lung Cancer (NSCLC) and Erlotinib-Resistant NSCLCFrontiers in OncologyJuly 30, 2019Man Yuan, Lin-feng Xu, Juan Zhang, Si-yuan Kong, Man Wu, Yuan-zhi Lao, Hua Zhou, Li Zhang, Hongxi XuS240/244-phospho-S6 (CST#5364), S6 (CST#2217), Y1068-phospho-EGFR (CST#2236), Y854phospho-EGFR (CST#6963), EGFR (CST#2236), p44/42 (CST#9107), phospho-p44/42 (CST#4370), AKT (CST#9272), and phospho-AKT (CST#9271).

(11) Candidalysin activates innate epithelial immune responses via epidermal growth factor receptorNature communicationsMay 24, 2019Ho J, Yang X, Nikou SA, Kichik N, Donkin A, Ponde NO, Richardson JP, Gratacap RL, Archambault LS, Zwirner CP, et al.infection, candidalysin exposure or mock treatment. Phospho-EGFR Tyr1068 (#3777), phospho-EGFR Tyr845 (#6963S), c-Fos (#2250S) and phospho-MKP1 (#2857S) antibodies were purchased from Cell Signalling Technology.

(12) Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung CancerCancer cellDecember 10, 2018Lee PC, Fang YF, Yamaguchi H, Wang WJ, Chen TC, Hong X, Ke B, Xia W, Wei Y, Zha Z, et al.Y1086),Abcam,Ab5650 EGFR (phospho Y1173),Cell Signaling Technology,4407 EGFR (phospho Y845),Cell Signaling Technology,6963 Her2,Cell Signaling Technology,2165 Axl,Genetex,GTX108560 Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204),Cell Signaling Technology

(13) FHL2 interacts with EGFR to promote glioblastoma growthOncogeneMarch 1, 2018Sun L, Yu S, Xu H, Zheng Y, Lin J, Wu M, Wang J, Wang A, Lan Q, Furnari F, et al.anti-FHL2 (K0055–3, MBL), anti-FLAG (F1804, Sigma), anti-pAKT(Ser473) (4060 s, CST), anti-pEGFR (4267 s, 6963 s, CST), and anti-Phosphotyrosine Antibody clone 4G10® (MAP3090, Upstate). Immunoprecipitate Cell

(14) Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signalingJournal of Cell ScienceJanuary 22, 2018Fiona N. Kenny, Zoe Drymoussi, Robin Delaine-Smith, Alexander P. Kao, Ana Catarina Laly, Martin M. Knight, Michael P. Philpott, John T. Connellysodium citrate. Sections were blocked as before and stained with anti-pEGFR Y845 (1:100, Cell Signaling, 6963S). Slides were imaged with a Leica DM5000B microscope, and mean fluorescence intensity of the basal layer

(15) Organotypic three-dimensional cancer cell cultures mirror drug responses in vivo: lessons learned from the inhibition of EGFR signalingOncotargetDecember 8, 2017Nico Jacobi et al.Cell Signaling Technology (Danvers, MA, USA): ErbB1 (#4267), ErbB2 (#2165), ErbB3 (#12708), phospho-ErbB1 Y845 (#6963), Y992 (#2235), Y1068 (#3777), Y1086 (#2220), Y1148 (#4404), phospho-ErbB2 Y1196 (#6942), phosphoErbB3

(16) The enhanced tumor inhibitory effects of gefitinib and L-ascorbic acid combination therapy in non-small cell lung cancer cellsOncology LettersJuly 1, 2017Kyoung Eun Lee, Eunsil Hahm, Seyeon Bae, Jae Seung Kang, Wang Jae Lee0.1% Tween‑20‑PBS; the antibodies included anti‑EGFR (cat. no. 4267S), anti‑p‑EGFR (Tyr845; cat. no. 6963S), anti‑p‑EGFR (Tyr992; cat. no. 2235S), anti‑p‑EGFR (Tyr1068; cat. no. 2234S), anti‑Akt (cat. no. 9272S)

(17) Increased Muscular 5α-Dihydrotestosterone in Response to Resistance Training Relates to Skeletal Muscle Mass and Glucose Metabolism in Type 2 Diabetic RatsPLOS ONENovember 10, 2016Naoki Horii, Koji Sato, Noboru Mesaki, Motoyuki Iemitsu

(18) Cyanidin-3-o-glucoside directly binds to ERα36 and inhibits EGFR-positive triple-negative breast cancerOncotargetOctober 18, 2016Li Wang et al.(Hanabryggene Technology Centre, Norway). The monoclonal and polyclonal antibodies for phospho-EGFR (Tyr845) (#6963), EGFR (#4267), phospho-AKT (Ser473) (#4060), cleaved-caspase-3 (#9664), caspase-3 (#9665), caspase-8

(19) Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancersNature communicationsOctober 3, 2016Kim JA, Tan Y, Wang X, Cao X, Veeraraghavan J, Liang Y, Edwards DP, Huang S, Pan X, Li K, et al.

(20) Wogonin inhibits the proliferation and invasion, and induces the apoptosis of HepG2 and Bel7402 HCC cells through NF-κB/Bcl-2, EGFR and EGFR downstream ERK/AKT signalingInternational Journal of Molecular MedicineOctober 1, 2016Xiaodong Liu, Shuo Tian, Mei Liu, Lingyan Jian, Limei Zhaowere incubated overnight at 4˚C with antibodies against p-ERK (4376), p-AKT (4060), p-EGFR (Tyr845; 6963), cyclin D1 (2978), MMP2 (4022), cyclin E (4129), Bcl-2 (15071), CDK4 (12790), CDK6 (3136), cleaved

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12/4/2015Phospho-EGFR (Tyr845) Antibody from Cell Signaling Haiquan LuThis antibody was used to detect the expression of phosphorylated EGFR at Tyr845 site in response to cetuximab treatment in HN5 human HNSCC cells by western blot.

Phospho-EGF Receptor (Tyr845) (D63B4) Rabbit mAb

Phospho-EGF Receptor (Tyr845) (D63B4) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

Citations (31)

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Phospho-EGF Receptor (Tyr845) (D63B4) Rabbit mAb from Cell Signaling Technology

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