L-Ascorbic acid from MilliporeSigma

Product Specs
ItemL-Ascorbic acid
CompanyMilliporeSigma
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberA4403
Molecular WeightM_w 176.12 g/mol
Applicationsmammalian cell culture, insect cell culture, plant cell culture
Quantity100MG

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MilliporeSigma

400 Summit Drive

Burlington, Massachusetts 01803

United States

Phone: (800)-645-5476
(800)-645-5439

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Website: www.SigmaAldrich.com/

(1) One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivoNeural Regeneration ResearchFebruary 1, 2024Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, et al.(Peprotech, AF-100-25) + transforming growth factor-β3 (Peprotech, AF-100-36E) + L-ascorbic acid (Sigma, A4403); medium used on days 17–25: Neurobasal + B27 + Glutamax + brain-derived neurotrophic factor + glial-derived

(2) Thioflavin T indicates mitochondrial membrane potential in mammalian cellsBiophysical ReportsDecember 13, 2023Emily Skates, Hadrien Delattre, Zoe Schofield, Munehiro Asally, Orkun S. Soyerdissolved in DMSO to make a 1 mM stock and stored at –20°C in the dark. Ascorbic acid (Sigma Aldrich, A4403) was dissolved in distilled water to make a 1 M stock solution, which was made fresh before every experiment. Fluorescence microscopy

(3) Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregsElifeDecember 6, 2023Huiyun Lyu, Guohua Yuan, Xinyi Liu, Xiaobo Wang, Shuang Geng, Tie Xia, Xuyu Zhou, Yinqing Li, Xiaoyu Hu, Yan Shidrug",InSolution Rapamycin,Sigma,553211, "Chemical compound, drug",L-Ascorbic acid (Vitamin C),Sigma,A4403, "Chemical compound, drug",AS2863619,MCE,HY-126675A, "Chemical compound, drug",BAY 11-7082,MCE,HY-13453, "Chemical

(4) Therapeutic effects of isoquercetin on ovariectomy-induced osteoporosis in miceNatural Products and BioprospectingDecember 1, 2023Mengjing Wu, Mengyu Qin, Xian WangGibco) (containing 10 mmol/L β-glycerophosphate (G9422, Sigma), 50 μmol/L ascorbic acid phosphate (A4403, Sigma), and 0.1 μmol/L dexamethasone (D4902, Sigma)). Adipogenic induction was performed with complete

(5) Enhancing osteogenic differentiation in adipose-derived mesenchymal stem cells with Near Infra-Red and Green PhotobiomodulationRegenerative TherapyDecember 1, 2023Daniella Da Silva, Anine Crous, Heidi Abrahamsedisodium (Sigma-Aldrich, South Africa, 50020) and [0.2 mM] ascorbic acid (Sigma-Aldrich, South Africa, A4403) osteogenic differentiation inducers. The cells were incubated for 7 days in osteogenic induction differentiation

(6) Developing a human iPSC-derived three-dimensional myelin spheroid platform for modeling myelin diseasesiScienceNovember 17, 2023Lizhao Feng, Jianfei Chao, Mingzi Zhang, Elizabeth Pacquing, Weidong Hu, Yanhong Shi291-G1-200 HGF,R&D,Cat# 294-HG-250 NT3,Peprotech,Cat# AF-450-03 Ascorbic acid,Millipore Sigma,Cat# A4403 NAA,Millipore Sigma,Cat# 00920 ,, Experimental models: Cell lines,Experimental models: Cell lines,Experimental models

(7) PI3K/AKT signaling activates HIF1α to modulate the biological effects of invasive breast cancer with microcalcificationnpj Breast CancerNovember 13, 2023Yao Tian, Lu Zhao, Zhengwei Gui, Shiyang Liu, Chenguang Liu, Tianyao Yu, Lin Zhang1), cells were cultured with calcified medium consisting of 50 μg/mL ascorbic acid (Sigma-Aldrich # A4403), 10 mM inorganic phosphate (Sigma-Aldrich, #71496), and 10–100 nM dexamethasone (Sigma-Aldrich, # D4902).

(8) Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivoNucleic Acids ResearchNovember 10, 2023Sukhleen Kour, Tyler Fortuna, Eric N Anderson, Darilang Mawrie, Jessica Bilstein, Ramakrishnan Sivasubramanian, Caroline Ward, Rishit Roy, Dhivyaa Rajasundaram, Jared Sterneckert, et al.plates in neurobasal-N2-B27 media containing growth factors (BDNF, GDNF, CNTF) and ascorbic acid (Sigma, A4403). The differentiated neurons were processed for subsequent immunofluorescence and western blot analyses

(9) Cadaveric Adipose-Derived Stem Cells for Regenerative Medicine and ResearchInternational Journal of Molecular SciencesOctober 28, 2023Lara Milián, Pilar Molina, María Oliver-Ferrándiz, Carlos Fernández-Sellers, Ana Monzó, Rafael Sánchez-Sánchez, Aitana Braza-Boils, Manuel Mata, Esther Zoriosupplement (Sigma-Merck KGaA, Germany, 41400–045), 50 µg/mL ascorbic acid (Sigma-Merck KGaA, Germany, A4403), 10 ng/mL TGF-β1 (Sigma-Merck KGaA, Germany, T7039), and 1% heat-inactivated FBS, as previously reported

(10) Human cerebrospinal fluid affects chemoradiotherapy sensitivities in tumor cells from patients with glioblastomaScience AdvancesOctober 27, 2023Brett W. Stringer, Manam Inushi De Silva, Zarina Greenberg, Alejandra Noreña Puerta, Robert Adams, Bridget Milky, Michael Zabolocki, Mark van den Hurk, Lisa M. Ebert, Christine Fairly Bishop, et al.FGF8b (100 ng/ml; PeproTech, catalog no. 100-25), 200 nM ascorbic acid (Sigma-Aldrich, catalog no. A4403), and laminin (1 μg/ml). Cortical neural progenitor medium consisted of DMEM/F12 + GlutaMAX plus SM1,

(11) HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formationBone ResearchOctober 23, 2023Yuheng Li, Weijia Sun, Jianwei Li, Ruikai Du, Wenjuan Xing, Xinxin Yuan, Guohui Zhong, Dingsheng Zhao, Zizhong Liu, Xiaoyan Jin, et al.medium with α-MEM containing 10% fetal bovine serum, an additional 50 μg·mL−1 ascorbic acid (Sigma, A4403), and 5 mmol·L−1 β-glycerophosphate (Sigma, G9422). RNA extraction and qPCR analysis Total RNA was

(12) Chromatin-modifying enzymes as modulators of nuclear size during lineage differentiationCell Death DiscoveryOctober 20, 2023Lingjun Meng100-47 H-FGF-basic-154,PeproTech,Cat# 10018B Insulin,Sigma-Aldrich,Cat# I6634 Heparin,Sigma,Cat# H3393 Ascorbic acid,Sigma,Cat# A4403 HEPES buffer solution,Gibco,Cat# 15630049 Matrigel,BD Biosciences,Cat# 356230 Polybrene,Sigma-Aldrich,Cat#

(13) Combined Molybdenum Gelatine Methacrylate Injectable Nano-Hydrogel Effective Against Diabetic Bone RegenerationInternational Journal of NanomedicineOctober 20, 2023Xun Liao, Mingkui Shen, Tengbo Li, Li Feng, Zhao Lin, Guang Shi, Guoxian Pei, Xiyu CaiSigma-Aldrich, Germany), 0.1 mM dexamethasone (D4902, Sigma Aldrich, Germany), and 300 mM ascorbic acid (A4403, Sigma-Aldrich, Germany) in the presence of GelMA or GelMA/POM. After culture for 14 days, the cell

(14) Development of a loop-mediated isothermal amplification (LAMP)-based electrochemical test for rapid detection of SARS-CoV-2iScienceSeptember 15, 2023Khushboo Borah Slater, Muhammad Ahmad, Aurore Poirier, Ash Stott, Bianca Sica Siedler, Matthew Brownsword, Jai Mehat, Joanna Urbaniec, Nicolas Locker, Yunlong Zhao, et al.Prevention, Division of Viral, Atlanta USA),",N/A Sulfuric acid,Merck,258105 L-Ascorbic acid,Merck,A4403 Ammonium molybdate tetrahydrate,Merck,A7302 Potassium antimony tartrate trihydrate,Merck,383376 Potassium

(15) Efficient genome editing in erythroid cells unveils novel MYB target genes and regulatory functionsiScienceSeptember 15, 2023Deleuze V, Garcia L, Rouaisnel B, Salma M, Kinoo A, Andrieu-Soler C, Soler E.proteins" ,, DMEM,Gibco,41965-039 IMDM,Gibco,319800-022 SVF,Eurobio,CVFSVF00-01 Antibiotique-antimycotique (100X),Gibco,15240096 ITS 100x,Gibco,I 3146 Ascorbic Acid,Sigma,A4403 a-thioglycerol,Sigma,M6145 Dexamethasone,Sigma,D2915 mSCF,Home made,N/A DMSO,Sigma,D8418 Erythropoietin,Peprotech,100-64 Puromycin,Gibco,A1113803 Neomycin

(16) Protocol for generating reproducible miniaturized controlled midbrain organoidsSTAR ProtocolsSeptember 1, 2023Muwan Chen, Jonathan Christos Niclis, Mark Denham04-0074 CHIR99021,Stemgent,Cat#04-0004-10 SAG,Millipore,Cat#566660 FGF8b,R&D Systems,Cat#423-F8 L-Ascorbic acid (AA),Sigma-Aldrich,Cat#A4403 DAPT,TOCRIS,Cat#2634 Recombinant Human GDNF,R&D Systems,Cat#212-GD-050 LM22A4,TOCRIS,Cat#4607 cAMP,Sigma-Aldrich,Cat#D0627 Paraformaldehyde

(17) A novel protocol to derive cervical motor neurons from induced pluripotent stem cells for amyotrophic lateral sclerosisStem Cell ReportsSeptember 1, 2023Meimei Yang, Min Liu, Yajaira Feller Sánchez, Sahar Avazzadeh, Leo R. Quinlan, Gang Liu, Yin Lu, Guangming Yang, Timothy O'Brien, David C. Henshall, et al.medium (21103049), 1% P/S (15140122), 0.5× N2 (17502048), 0.5× B27 (17504044), 0.1 mM ascorbic acid (AA, A4403, Sigma), and 1% GlutaMAX (35050061) from Gibco. The medium was renewed every other day with fresh 3

(18) Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1NeuronAugust 16, 2023Pilotto F, Douthwaite C, Diab R, Ye X, Al Qassab Z, Tietje C, Mounassir M, Odriozola A, Thapa A, Buijsen RAM, et al.,Stem cell technologies,Cat#72147 CHIR99021,Stem cell technologies,Cat#72052 L-Ascorbic Acid,Sigma Aldrich,Cat#A4403 SAG,Stem cell technologies,Cat#73412 BDNF,Stem cell technologies,Cat#78005 DAPT,Stem cell technologies,Cat#72082 GDNF,Stem cell technologies

(19) Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variantsNature communicationsJuly 26, 2023de Melo GD, Perraud V, Alvarez F, Vieites-Prado A, Kim S, Kergoat L, Coleon A, Trüeb BS, Tichit M, Piazza A, et al.CultureOne supplement (A3320201, Gibco), 2 mM glutamax (35050038, Gibco), and 200 µM ascorbic acid (A4403, Sigma Aldrich) and incubated at 37 °C in 5% CO2 for 14 days, replacing half of the medium every other

(20) EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblastsBlood AdvancesJuly 25, 2023Ji Wu, Kenta Moriwaki, Tatsuya Asuka, Ritsuko Nakai, Satoshi Kanda, Manabu Taniguchi, Tatsuki Sugiyama, Shin-ichiro Yoshimura, Masataka Kunii, Takashi Nagasawa, et al.fetal calf serum, 1× ITS liquid medium (Sigma-Aldrich, I3146), 50 μg/mL ascorbic acid (Sigma-Aldrich, A4403), 0.45 mM α-monothioglycerol (Wako, 195-15791), 50 ng/mL recombinant mouse stem cell factor (BioLegend,

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L-Ascorbic acid from MilliporeSigma

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L-Ascorbic acid from MilliporeSigma

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