LRRK2 ELISA kits are immunoassay tools for the measurement of the protein leucine rich repeat kinase 2, which is encoded by the LRRK2 gene in humans. Functionally, this protein is reported to be a serine/threonine-protein kinase, which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, autophagy, and vesicle trafficking. The canonical protein structure is reported to have an amino acid length of 2527 residues, a mass of 286.1 kDa, and is a member of the TKL Ser/Thr protein kinase protein family. It is known to be localized in the cytoplasm and is reported to be expressed in pyramidal neurons in all cortical laminae of the visual cortex, in neurons of the substantia nigra pars compacta and caudate putamen. The protein has been noted to be post-translationally ubiquitinated and phosphorylated. The LRRK2 gene has been associated with the disease, Parkinson disease. Other alias names for this target include leucine-rich repeat serine/threonine-protein kinase 2 and augmented in rheumatoid arthritis 17.
Some LRRK2 ELISA kits can detect targets at levels as low as 20 ng/L and as high as 20 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.