MEFV ELISA kits are immunoassay tools for the measurement of the protein MEFV innate immunity regulator, pyrin, which is encoded by the MEFV gene in humans. Functionally, this protein is reported to be involved in regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. The canonical protein structure is reported to have an amino acid sequence of 781 residues and a mass of 86.4 kDa. It is known to be localized in the nucleus, cytoplasmic vesicles, and cytoplasm and is reported to be expressed in peripheral blood leukocytes, particularly in mature granulocytes and to a lesser extent in monocytes but not in lymphocytes. As many as 3 protein isoforms have been reported. The protein has been noted to be post-translationally cleaved and phosphorylated. The MEFV gene has been associated with the disease, Familial Mediterranean fever. Other alias names for this target include MEF, PAAND, TRIM20, pyrin, MEFV innate immuity regulator, pyrin, and FMF.
Some MEFV ELISA kits can detect targets at levels as low as 15 ng/L and as high as 50 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.