RRM2B ELISA kits are immunoassay tools for the measurement of the protein ribonucleotide reductase regulatory TP53 inducible subunit M2B, which is encoded by the RRM2B gene in humans. Functionally, this protein is known to play a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. The canonical protein structure is reported to have an amino acid length of 351 residues, a mass of 40.7 kDa, and is a member of the Ribonucleoside diphosphate reductase small chain protein family. It is known to be localized in the nucleus and cytoplasm and is found to be widely expressed at a high level in skeletal muscle and at a weak level in thymus. As many as 6 protein isoforms have been reported. The RRM2B gene has been associated with the disease, Mitochondrial DNA depletion syndrome. Other alias names for this target include MTDPS8B, P53R2, RCDFRD, ribonucleoside-diphosphate reductase subunit M2 B, and MTDPS8A.
The detection range for different RRM2B ELISA kits can vary, with some assays measuring target concentrations as low as 47 pg/mL and as high as 10 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.