The following SprT-like N-terminal domain ELISA kits are useful research tools for the measurement of SprT-like N-terminal domain in biological samples. In humans this protein is encoded by the SPRTN gene. This protein is reported to be a DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. The canonical protein structure is reported to have an amino acid length of 489 residues, a mass of 55.1 kDa, and is a member of the Spartan protein family. Its subcellular location is known to be in the nucleus. As many as 3 protein isoforms have been reported. In certain instances, it is also post-translationally ubiquitinated, acetylated, cleaved and phosphorylated. The gene encoding this protein has been associated with the disease, Ruijs-Aalfs syndrome. This protein may also be known as DNA damage protein targeting VCP, DNA damage-targeting VCP (p97) adaptor, zinc finger RAD18 domain-containing protein, and DNA-dependent metalloprotease SPRTN.
There are SprT-like N-terminal domain ELISA kits that can detect a target at concentrations as low as 0.156 ng/mL and as high as 10 ng/mL. Use the search filters to narrow your search and click on the ELISA kits below for more detailed information, such as reactivity and assay sensitivity.