Anti-CLEC4M antibodies are used in the immunodetection of the protein C-type lectin domain family 4 member M. In humans, the canonical protein has a reported length of 399 amino acid residues and a mass of 45.4 kDa. Its subcellular localization is in the cell membrane and is secreted. Up to 1 different isoforms have been reported for this protein. It is notably expressed in the testis, colon, and cerebral cortex. CLEC4M is a suspected pathogen-recognition receptor involved in peripheral immune surveillance in liver. Post-translational modifications have been described, including glycosylation. The CLEC4M marker can be used to identify Lymphatic Vessel Endothelial Cells.* Synonyms for this target antigen include CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN, and CD209L. CLEC4M gene orthologs have been reported in the mouse, rat and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4