Anti-RTCA antibodies are used in the immunodetection of the protein RNA 3'-terminal phosphate cyclase. In humans, the canonical protein has a reported length of 366 amino acid residues and a mass of 39.3 kDa. Its subcellular localization is in the nucleus. Up to 2 different isoforms have been reported for this protein. It is ubiquitously expressed across many tissue types. A member of the RNA 3'-terminal cyclase protein family, RTCA is known to catalyze the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. Synonyms for this target antigen include RTC1, RTCD1, RNA terminal phosphate cyclase domain 1, RNA terminal phosphate cyclase domain-containing protein 1, RTC domain-containing protein 1, and RPC. RTCA gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some RTCA antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.