GRG3, or Transducin like enhancer of split 3, is a human gene encoded by TLE3. It may also be known as: Transducin-like enhancer protein 3; ESG3; Enhancer of split groucho-like protein 3; ESG; HsT18976; transducin-like enhancer of split 3. The encoded protein has an amino acid length of 772 and a mass of 83.4 kDa. Other isoforms may exist. GRG3 is a member of the WD repeat Groucho/TLE family. Homologs of this gene exist in other organisms, including: Mouse, Rat, Frog, Chicken.