DCAF1, or Vpr (HIV-1) binding protein, is a human gene encoded by VPRBP. It may also be known as: Protein VPRBP; VprBP; Serine/threonine-protein kinase VPRBP; DDB1- and CUL4-associated factor 1; HIV-1 Vpr-binding protein; DDB1 and CUL4 associated factor 1. The encoded protein is an enzyme with an amino acid length of 1507 and a mass of 169.0 kDa. Other isoforms may exist. DCAF1 is a member of the VPRBP/DCAF1 family. Homologs of this gene exist in other organisms, including: Mouse, Fly, Rat, Frog, Chicken.