Anti-Adenylate Cyclase 2 antibodies are used in the immunodetection of the protein encoded by the ADCY2 gene. In humans, the canonical protein has a reported length of 1091 amino acid residues and a mass of 123.6 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is notably expressed in zona glomerulosa and zona fasciculata in the adrenal gland. A member of the Adenylyl cyclase class-4/guanylyl cyclase protein family, it is known to catalyze the formation of the signaling molecule cAMP in response to G-protein signaling. Post-translational modifications have been described, including phosphorylation and glycosylation. Other names for this target antigen include HBAC2, adenylate cyclase type 2, 3',5'-cyclic AMP synthetase, ATP pyrophosphate-lyase 2, adenylate cyclase 2 (brain), and AC2.