Anti-LRP5 antibodies are used in the immunodetection of the protein LDL receptor related protein 5. In humans, the canonical protein has a reported length of 1615 amino acid residues and a mass of 179.1 kDa. Its subcellular localization is in the ER and membrane. It is found to be widely expressed, with the highest level of expression in the liver and in aorta. A member of the LDLR protein family, LRP5 is known to act as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Post-translational modifications have been described, including phosphorylation and glycosylation. Synonyms for this target antigen include EVR1, EVR4, HBM, LR3, LRP-7, LRP7, OPPG, and BMND1. LRP5 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 50 citations in the literature describe the use of LRP5 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.