Anti-NR4A2 antibodies are used in the immunodetection of the protein nuclear receptor subfamily 4 group A member 2. In humans, the canonical protein has a reported length of 598 amino acid residues and a mass of 66.6 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. A member of the Nuclear hormone receptor protein family, NR4A2 is a reported transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development.
The NR4A2 marker can be used to identify Medulla Oblongata Splatter Neurons, Ventral Excitatory Neurons, and T Follicular Helper Cells.* Synonyms for this target antigen include IDLDP, NOT, NURR1, RNR1, TINUR, and HZF-3. NR4A2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 80 citations in the literature describe the use of NR4A2 antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4