Anti-SPPL3 antibodies are used in the immunodetection of the protein signal peptide peptidase like 3. In humans, the canonical protein has a reported length of 384 amino acid residues and a mass of 42.3 kDa. Its subcellular localization is in the ER and Golgi. Up to 2 different isoforms have been reported for this protein. It is widely expressed across many tissue types. A member of the Peptidase A22B protein family, SPPL3 is known to be involved with the regulation of intracellular calcium. Synonyms for this target antigen include intramembrane protease 2, presenilin homologous protein 1, presenilin-like protein 4, and SPP-like 3. SPPL3 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Western Blot is a widely used application for the SPPL3 antibodies listed below. In addition, ELISA is also a common application.