Anti-centromere protein P antibodies are used in the immunodetection of the protein encoded by the CENPP gene. In humans, the canonical protein has a reported length of 288 amino acid residues and a mass of 33.2 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the CENP-P/CTF19 protein family, it is a known component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.