Anti-LRP6 antibodies are used in the immunodetection of the protein LDL receptor related protein 6. In humans, the canonical protein has a reported length of 1613 amino acid residues and a mass of 180.4 kDa. Its subcellular localization is in the ER and cell membrane. It is reported to be widely coexpressed with LRP5 during embryogenesis and in adult tissues. A member of the LDLR protein family, LRP6 is a known component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Synonyms for this target antigen include STHAG7, low-density lipoprotein receptor-related protein 6, and ADCAD2. LRP6 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 680 citations in the literature describe the use of LRP6 antibodies in research. ELISA is a widely used application for these antibodies. Western Blot and Immunohistochemistry are also common applications.