Anti-SIM1 antibodies are used in the immunodetection of the protein SIM bHLH transcription factor 1. In humans, the canonical protein has a reported length of 766 amino acid residues and a mass of 85.5 kDa. Its subcellular localization is in the nucleus. SIM1 is reported to be a transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. The SIM1 marker can be used to identify Hypothalamus Mammillary Body Neurons and Hypothalamus Splatter Neurons.* Synonyms for this target antigen include single-minded homolog 1, class E basic helix-loop-helix protein 14, single-minded family bHLH transcription factor 1, and bHLHe14. SIM1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some SIM1 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4