Anti-SPCS2 antibodies are used in the immunodetection of the protein signal peptidase complex subunit 2. In humans, the canonical protein has a reported length of 226 amino acid residues and a mass of 25 kDa. Its subcellular localization is in the ER. It is notably widely expressed in many tissue types. A member of the SPCS2 protein family, SPCS2 is a known component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Synonyms for this target antigen include microsomal signal peptidase 25 kDa subunit, signal peptidase 25kDa subunit, signal peptidase complex subunit 2 homolog, and SPase 25 kDa subunit. SPCS2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some SPCS2 antibodies may have been used in research and have associated citations. These antibodies are most commonly used in Western Blot experiments, among other applications.