Anti-UGCG antibodies are used in the immunodetection of the protein UDP-glucose ceramide glucosyltransferase. In humans, the canonical protein has a reported length of 394 amino acid residues and a mass of 44.9 kDa. Its subcellular localization is in the Golgi. It is reported to be found in all tissues examined. A member of the Glycosyltransferase 2 protein family, UGCG is known to participate in the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway at the cytosolic surface of the Golgi.
The UGCG marker can be used to identify Thymic Plasmacytoid Dendritic Cells.* Synonyms for this target antigen include GLCT1, ceramide glucosyltransferase, UDP-glucose:N-acylsphingosine D-glucosyltransferase, glucosylceramide synthase, glycosylceramide synthase, and GCS. UGCG gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of UGCG antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.
*HuBMAP Human Reference Atlas v1.4