Anti-SP140 antibodies are used in the immunodetection of the protein SP140 nuclear body protein. In humans, the canonical protein has a reported length of 867 amino acid residues and a mass of 98.2 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 6 different isoforms have been reported for this protein. It is notably expressed in spleen and peripheral blood leukocytes, much lower levels in tonsils, thymus, prostate, ovary, small intestine, and colon. SP140 is a known component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. Synonyms for this target antigen include LYSP100-A, LYSP100-B, nuclear body protein SP140, lymphoid-restricted homolog of Sp100, lymphoid-specific SP100 homolog, and LYSP100. SP140 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. A number of SP140 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.