Anti-Thioredoxin 2 antibodies are used for the immunodetection of the protein encoded by the TXN2 gene. In humans, the canonical protein has a reported length of 166 amino acid residues and a mass of 18.4 kDa. Its subcellular localization is in the mitochondria. It is found to be widely expressed in adult and fetal tissues. A member of the Thioredoxin protein family, it is known to be important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. The gene encoding this protein is implicated in Combined oxidative phosphorylation deficiency. Other names for this target antigen include MT-TRX, MTRX, TRX2, TXN, thioredoxin, mitochondrial, mitochondrial thioredoxin, and COXPD29. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 50 citations in the literature describe the use of Thioredoxin 2 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.