Anti-ECSCR antibodies are used in the immunodetection of the protein endothelial cell surface expressed chemotaxis and apoptosis regulator. In humans, the canonical protein has a reported length of 205 amino acid residues and a mass of 21.3 kDa. Its subcellular localization is in the cell membrane and cytoplasm. It is reported to be highly expressed in endothelial cells. A member of the ECSCR protein family, ECSCR is reported to regulate endothelial chemotaxis and tube formation. Post-translational modifications have been described, including O-glycosylation.
The ECSCR marker can be used to identify Aerocyte Capillary (aCap) Cells, Cap1 General Capillary (cGap) Cells, Respiratory Vein Endothelial Cells, Respiratory Lymphatic Vessel Endothelial Cells, and Pulmonary Artery Endothelial Cells.* Synonyms for this target antigen include apoptosis regulator through modulating IAP expression, endothelial cell-specific molecule 2, and endothelial cell-specific chemotaxis regulator. ECSCR gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. Some ECSCR antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4