Anti-ryanodine receptor 3 antibodies are used for the immunodetection of the protein encoded by the RYR3 gene. In humans, the canonical protein has a reported length of 4870 amino acid residues and a mass of 552 kDa. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the Ryanodine receptor (TC 1.A.3.1) protein family, it is reported to be a calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. Other names for this target antigen include brain ryanodine receptor-calcium release channel, brain-type ryanodine receptor, type 3 ryanodine receptor, and CMYP20. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of ryanodine receptor 3 antibodies have been mentioned in research publications and have associated citations. Immunohistochemistry is a widely used application for these antibodies. ELISA, Western Blot, Immunocytochemistry, and Immunofluorescence are also common applications.