Anti-profilin 1 antibodies are used for the immunodetection of the protein encoded by the PFN1 gene. In humans, the canonical protein has a reported length of 140 amino acid residues and a mass of 15.1 kDa. Its subcellular localization is in the cytoplasm. It is reported to be expressed in epididymis. A member of the Profilin protein family, it is known to bind to actin and affects the structure of the cytoskeleton. Post-translational modifications have been described, including phosphorylation. The gene encoding this protein is implicated in Amyotrophic lateral sclerosis. Other names for this target antigen include epididymis tissue protein Li 184a, profilin I, and ALS18. Gene orthologs have been identified in the mouse, rat, bovine and chimpanzee species. Over 120 citations in the literature describe the use of profilin 1 antibodies in research. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.