Anti-ITLN1 antibodies are used in the immunodetection of the protein intelectin 1. In humans, the canonical protein has a reported length of 313 amino acid residues and a mass of 35 kDa. Its subcellular localization is in the cell membrane and is secreted. It is reported to be highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue. ITLN1 is a reported lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Post-translational modifications have been described, including N-glycosylation. The ITLN1 marker can be used to identify Visceral Pleura Mesothelial Cells.* Synonyms for this target antigen include galactofuranose-binding lectin, intelectin 1 (galactofuranose binding), intestinal lactoferrin receptor, and endothelial lectin HL-1. ITLN1 gene orthologs have been reported in the mouse, rat and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4