Anti-pyruvate kinase L/R antibodies are used for the immunodetection of the protein encoded by the PKLR gene. In humans, the canonical protein has a reported length of 574 amino acid residues and a mass of 61.8 kDa. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Pyruvate kinase protein family, it is reported to be a pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis. The gene encoding this protein is implicated in Pyruvate kinase hyperactivity. Other names for this target antigen include PKL, PKRL, RPK, pyruvate kinase PKLR, R-type/L-type pyruvate kinase, and PK1. Gene orthologs have been identified in the mouse, rat, bovine, frog and chimpanzee species. A number of pyruvate kinase L/R antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.