Anti-matrix Gla protein antibodies are used for the immunodetection of the protein encoded by the MGP gene. In humans, the canonical protein has a reported length of 103 amino acid residues and a mass of 12.4 kDa. It is known to be a secreted protein. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Osteocalcin/matrix Gla protein family, it is reported to associate with the organic matrix of bone and cartilage.
The matrix Gla protein marker can be used to characterize Brain Vascular Non-Neuronal Cells, Pericytes, and Type 2 Thymic Fibroblasts.* Other names for this target antigen include MGLAP, NTI, cell growth-inhibiting gene 36 protein, and GIG36. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of matrix Gla protein antibodies have been mentioned in research publications and have associated citations. Western Blot and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4