Anti-centromere protein K antibodies are used for the immunodetection of the protein encoded by the CENPK gene. In humans, the canonical protein has a reported length of 269 amino acid residues and a mass of 31.7 kDa. Its subcellular localization is in the nucleus. It is notably expressed in several fetal organs with highest levels in fetal liver. A member of the CENP-K/MCM22 protein family, it is a known component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Other names for this target antigen include interphase centromere complex protein 37, leucine zipper protein FKSG14, protein AF-5alpha, and SoxLZ/Sox6-binding protein Solt. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.