Anti-Ataxin 1 antibodies are used in the immunodetection of the protein encoded by the ATXN1 gene. In humans, the canonical protein has a reported length of 815 amino acid residues and a mass of 86.9 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is reported to be widely expressed throughout the body. A member of the ATXN1 protein family, it is reported to be a chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Post-translational modifications have been described, including ubiquitination, sumoylation and phosphorylation. Other names for this target antigen include D6S504E, SCA1, alternative ataxin1, spinocerebellar ataxia type 1 protein, and ATX1.