Anti-Angel Homolog 2 antibodies are used in the immunodetection of the protein encoded by the ANGEL2 gene. In humans, the canonical protein has a reported length of 544 amino acid residues and a mass of 62.3 kDa. Alternative splicing is reported to yield 2 different isoforms for this protein. The angel homolog 2 protein is a member of the CCR4/nocturin protein family. Other names for this target antigen include protein angel homolog 2.