Anti-LAMP2 antibodies are used in the immunodetection of the protein lysosomal associated membrane protein 2. In humans, the canonical protein has a reported length of 410 amino acid residues and a mass of 45 kDa. Its subcellular localization is in the cytoplasmic vesicles, lysosomes, and cell membrane. Up to 3 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the LAMP protein family, LAMP2 is known to play an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. Post-translational modifications have been described, including N-glycosylation. The LAMP2 gene has been associated with the disease, Danon disease. Synonyms for this target antigen include DND, LAMPB, LGP-96, LGP110, lysosome-associated membrane glycoprotein 2, and CD107b. LAMP2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.