Anti-HS3ST3A1 antibodies are used in the immunodetection of the protein heparan sulfate-glucosamine 3-sulfotransferase 3A1. In humans, the canonical protein has a reported length of 406 amino acid residues and a mass of 44.9 kDa. Its subcellular localization is in the Golgi. It is ubiquitously expressed across many tissue types. A member of the Sulfotransferase 1 protein family, HS3ST3A1 is a reported sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Post-translational modifications have been described, including glycosylation.
The HS3ST3A1 marker can be used to identify Choroid Plexus Non-Neuronal Cells and Gray Matter CGE Interneurons.* Synonyms for this target antigen include 3OST3A1, heparan sulfate glucosamine 3-O-sulfotransferase 3A1, heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1, heparan sulfate 3-O-sulfotransferase 3A1, and 3-OST-3A. HS3ST3A1 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4