Anti-Aquaporin 5 antibodies are used for the immunodetection of the protein encoded by the AQP5 gene. In humans, the canonical protein has a reported length of 265 amino acid residues and a mass of 28.3 kDa. Its subcellular localization is in the cytoplasmic vesicles and cell membrane. It is notably expressed in skin eccrine sweat glands, at the apical cell membrane and at intercellular canaliculi. It is a member of the MIP/aquaporin (TC 1.A.8) protein family. Post-translational modifications have been described, including glycosylation. The gene encoding this protein is implicated in Keratoderma. Other names for this target antigen include PPKB. Gene orthologs have been identified in the mouse, rat, bovine, chimpanzee and chicken species.