Anti-TG antibodies are used in the immunodetection of the protein thyroglobulin. In humans, the canonical protein has a reported length of 2768 amino acid residues and a mass of 304.8 kDa. It has been described to be a secreted protein. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the thyroid gland. A member of the Type-B carboxylesterase/lipase protein family, TG is known to act as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Post-translational modifications have been described, including protein cleavage, sulfation and glycosylation.
The TG marker can be used to identify Amygdala Excitatory Neurons.* Synonyms for this target antigen include AITD3 and TGN. TG gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 60 citations in the literature describe the use of TG antibodies in research. These antibodies are most commonly used in Immunohistochemistry experiments, among other applications.
*HuBMAP Human Reference Atlas v1.4