Anti-ALKBH8 antibodies are used in the immunodetection of the protein alkB homolog 8, tRNA methyltransferase. In humans, the canonical protein has a reported length of 664 amino acid residues and a mass of 75.2 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 4 different isoforms have been reported for this protein. It is found to be widely expressed, with highest expression in spleen, followed by pancreas and lung. A member of the AlkB protein family, ALKBH8 is known to catalyze the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. The ALKBH8 gene has been associated with the disease, Intellectual developmental disorder. Synonyms for this target antigen include AlkB homologue 8, S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8, alkB, alkylation repair homolog 8, and alkylated DNA repair protein alkB homolog 8. Some ALKBH8 antibodies may have been used in research and have associated citations. Immunohistochemistry is a widely used application for these antibodies. Western Blot and Immunofluorescence are also common applications.