Anti-HPGD antibodies are used in the immunodetection of the protein 15-hydroxyprostaglandin dehydrogenase. In humans, the canonical protein has a reported length of 266 amino acid residues and a mass of 29 kDa. Its subcellular localization is in the cytoplasm. Up to 5 different isoforms have been reported for this protein. It is notably expressed in colon epithelium. A member of the Short-chain dehydrogenases/reductases (SDR) protein family, HPGD is known to catalyze the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites.
The HPGD marker can be used to identify Common Myeloid Progenitors (CMP) and Thalamus Splatter Neurons.* Synonyms for this target antigen include PGDH, PGDH1, PHOAR1, SDR36C1, 15-hydroxyprostaglandin dehydrogenase [NAD(+)], and 15-PGDH. HPGD gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 60 citations in the literature describe the use of HPGD antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Flow Cytometry, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4