Anti-HCLS1 antibodies are used in the immunodetection of the protein hematopoietic cell-specific Lyn substrate 1. In humans, the canonical protein has a reported length of 486 amino acid residues and a mass of 54 kDa. Its subcellular localization is in the membrane, mitochondria, and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is found to be preferentially expressed in tissues and cells of hematopoietic origin. HCLS1 is known to be involved with cytokine-mediated signaling pathways and erythrocyte differentiation. Post-translational modifications have been described, including phosphorylation. Synonyms for this target antigen include HS1, lckBP1, p75, hematopoietic lineage cell-specific protein, and CTTNL. HCLS1 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. A number of HCLS1 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.