Anti-DIABLO antibodies are used in the immunodetection of the protein diablo IAP-binding mitochondrial protein. In humans, the canonical protein has a reported length of 239 amino acid residues and a mass of 27.1 kDa. Its subcellular localization is in the mitochondria. Up to 3 different isoforms have been reported for this protein. It is widely expressed across many tissue types. DIABLO is reported to promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Post-translational modifications have been described, including ubiquitination. Synonyms for this target antigen include diablo-like protein, direct IAP-binding protein with low pI, second mitochondria-derived activator of caspase, and diablo homolog, mitochondrial. DIABLO gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 120 citations in the literature describe the use of DIABLO antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.