Anti-Mitofusin 1 antibodies are used in the immunodetection of the protein encoded by the MFN1 gene. In humans, the canonical protein has a reported length of 741 amino acid residues and a mass of 84.2 kDa. Its subcellular localization is in the mitochondria and cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. It is notably expressed in kidney and heart. A member of the Dynamin/Fzo/YdjA protein family, it is known to be involved with metabolic processes. Post-translational modifications have been described, including ubiquitination. Other names for this target antigen include mitochondrial transmembrane GTPase FZO-2, mitochondrial transmembrane GTPase Fzo-1, putative transmembrane GTPase, transmembrane GTPase MFN1, and fzo homolog.