Anti-mono-ADP ribosylhydrolase 2 antibodies are used for the immunodetection of the protein encoded by the MACROD2 gene. In humans, the canonical protein has a reported length of 425 amino acid residues and a mass of 47.4 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 5 different isoforms for this protein. It is noted to be involved in brain development and DNA damage pathways. Other names for this target antigen include MACRO domain containing 2, MACRO domain-containing protein 2, O-acetyl-ADP-ribose deacetylase MACROD2, [Protein ADP-ribosylaspartate] hydrolase MACROD2, and ADP-ribose glycohydrolase MACROD2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.