Anti-IRAG1 antibodies are used in the immunodetection of the protein inositol 1,4,5-triphosphate receptor associated 1. In humans, the canonical protein has a reported length of 904 amino acid residues and a mass of 98 kDa. Its subcellular localization is in the cytoplasm. Up to 9 different isoforms have been reported for this protein. It is reported to be expressed in the colon, rectum, and cultured colonic smooth muscle. IRAG1 is reported to play a role in as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Post-translational modifications have been described, including phosphorylation. Synonyms for this target antigen include JAW1L, MRVI1, IP3R-associated cGMP kinase substrate, JAW1-related protein MRVI1, and IRAG. IRAG1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.