Anti-crumbs cell polarity complex component 1 antibodies are used for the immunodetection of the protein encoded by the CRB1 gene. In humans, the canonical protein has a reported length of 1406 amino acid residues and a mass of 154.2 kDa. Its subcellular localization is in the cell membrane and is secreted. Alternative splicing is reported to yield 5 different isoforms for this protein. A member of the Crumbs protein family, it is reported to play a role in photoreceptor morphogenesis in the retina (By similarity). Post-translational modifications have been described, including glycosylation. The gene encoding this protein is implicated in Retinitis pigmentosa. Other names for this target antigen include CRB1-B, CRB1-C, LCA8, RP12, protein crumbs homolog 1, and CRB1-A. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.