Anti-mediator complex subunit 13L antibodies are used for the immunodetection of the protein encoded by the MED13L gene. In humans, the canonical protein has a reported length of 2210 amino acid residues and a mass of 242.6 kDa. Its subcellular localization is in the nucleus. It is reported to be highly expressed in the brain (cerebellum), heart (aorta), skeletal muscle, kidney, placenta and peripheral blood leukocytes. A member of the Mediator complex subunit 13 protein family, it is a known component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. The gene encoding this protein is implicated in Impaired intellectual development and distinctive facial features with or without cardiac defects. Other names for this target antigen include PROSIT240, THRAP2, TRAP240L, mediator of RNA polymerase II transcription subunit 13-like, and MRFACD. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.