Anti-ADP-ribosylserine hydrolase antibodies are used for the immunodetection of the protein encoded by the ADPRS gene. In humans, the canonical protein has a reported length of 363 amino acid residues and a mass of 38.9 kDa. Its subcellular localization is in the nucleus, mitochondria, and cytoplasm. It is ubiquitously expressed across many tissue types. A member of the ADP-ribosylglycohydrolase protein family, it is a reported ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. The gene encoding this protein is implicated in Neurodegeneration. Other names for this target antigen include ARH3, CONDSIAS, ADP-ribosylhydrolase ARH3, ADP-ribose glycohydrolase ARH3, ADP-ribosylarginine hydrolase like 2, and ADPRHL2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.