Anti-SPG11 vesicle trafficking associated, spatacsin antibodies are used for the immunodetection of the protein encoded by the SPG11 gene. In humans, the canonical protein has a reported length of 2443 amino acid residues and a mass of 278.9 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. It is reported to be expressed in all structures of brain, with a high expression in cerebellum. It is believed to play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. The gene encoding this protein is implicated in Spastic paraplegia. Other names for this target antigen include SPG11, spatacsin vesicle trafficking associated, amyotrophic lateral sclerosis 5, colorectal carcinoma-associated protein, spastic paraplegia 11 (autosomal recessive), and spatacsin. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.