Anti-adenylosuccinate synthase 1 antibodies are used for the immunodetection of the protein encoded by the ADSS1 gene. In humans, the canonical protein has a reported length of 457 amino acid residues and a mass of 50.2 kDa. Its subcellular localization is in the cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be highly expressed in the skeletal muscle and heart, as well as in several hematopoietic cell lines and solid tumors. A member of the Adenylosuccinate synthetase protein family, it is a known component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Other names for this target antigen include AMPSase 1, IMP--aspartate ligase 1, M-type adenylosuccinate synthetase, adenylosuccinate synthase like 1, adenylosuccinate synthetase, basic isozyme, and adenylosuccinate synthetase isozyme 1. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.