Anti-SRY-box transcription factor 6 antibodies are used for the immunodetection of the protein encoded by the SOX6 gene. In humans, the canonical protein has a reported length of 828 amino acid residues and a mass of 91.9 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 4 different isoforms for this protein. It is reported to be expressed in a wide variety of tissues, most abundantly in skeletal musclen. It is reported to be a transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Post-translational modifications have been described, including sumoylation. The gene encoding this protein is implicated in Tolchin-Le Caignec syndrome. Other names for this target antigen include SRY (sex determining region Y)-box 6, SRY-box 6, SRY-box containing gene 6, and transcription factor SOX-6. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.