Anti-UPF2 regulator of nonsense mediated mRNA decay antibodies are used for the immunodetection of the protein encoded by the UPF2 gene. In humans, the canonical protein has a reported length of 1272 amino acid residues and a mass of 147.8 kDa. Its subcellular localization is in the cytoplasm. It is ubiquitously expressed across many tissue types. It is known to be involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Other names for this target antigen include RENT2, smg-3, regulator of nonsense transcripts 2, FRS2/UPF2/LEMD3 fusion, LEMD3/UPF2 fusion, and HUPF2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.