Anti-transmembrane immune signaling adaptor TYROBP antibodies are used for the immunodetection of the protein encoded by the TYROBP gene. In humans, the canonical protein has a reported length of 113 amino acid residues and a mass of 12.2 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 3 different isoforms for this protein. It is reported to be expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. A member of the TYROBP protein family, it is reported to be an adapter protein, which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors. Other names for this target antigen include KARAP, PLOSL, PLOSL1, TYRO protein tyrosine kinase-binding protein, DNAX adaptor protein 12, and DAP12. Gene orthologs have been identified in the mouse, rat, bovine and chimpanzee species.